Sunday, 08 April 2018 22:36

2017/18 M Fraccaro Lecture

The 2017/18 M Fraccaro Lecture, organised an nually by Collegio Cairoli and Collegio Volta will be given at 5.00 pm on 9th April 2018 in the main University lecture hall (Aula Magna) by Prof M De Luca at the University of Modena. 

The lecture entitled: Life-saving regeneration of the entire human epidermis by transgenic stem cells and will illustrate ground-breaking progress in curing a child with a life-threatening skis disease (Junctional epidermolysis bullosa, genetic disease caused by mutations in genes encodingthe basement membrane component laminin 5). The approach pursued by Prof M De Luca and his collaborators involved correction of the faulty gene in skin stem cells in culture followed by propagation and implantation of the cells with the corrected gene to enable the growth of the entire body skin. The results of this study were published in November 2017 in the journal Nature and the article is available here for downloading.

All College students are warmly invited to attend this important lecture.  The poster of the lecture can be downloaded here.  The lecture will be followed by refreshments at Collegio Cairoli.

Image: a human skin cell, known as keratinocyte, in culture.

New directions in optical microscopy

21th March 2018.  
W Brad Amos, MRC Laboratory of Molecular Biology, Cambridge              

Abstract 
The fourth seminar of the Light microscopy series will be given by William B Amos of the MRC Laboratory of Molecular Biology in Cambridge in the College lecture theatre on Wednesday the 21st of March at 2.00 pm and will address New directions in optical microscopy. The seminar will cover: Multiphoton microscopy on the one hand and Super-resolution methods on the other.  The latter inclu Optical (structured Illumination) and Photochemical (Stimulated Emission Depletion STED, Stochastic optical reconstruction, STORM and Photoactivation Light Microscopy PALM)discuss standardised distances in compound microscopes, lens aberrations, diffraction in the light microscope, Rayleigh resolution and Fourier synthesis. The poster of the series can be downloaded here.

Biography
William Brad Amos was trained as a zoologist, researched in cell biology and is now a designer of optical instruments. With John White, Mick Fordham and Richard Durbin in Cambridge, he developed an instrument that has set the standard of modern confocal microscopes.  Derivatives of this instrument are now made by many companies and are in use throughout the world. His scientific work is now carried out done in collaboration with Gail McConnell in the University of Strathclyde. This collaboration has resulted in several novel applications of optical physics in microscopy, including what is arguably the greatest design change in microscope objectives  for 100 years. This is called the Mesolens, the name signifying that it has the wide field of a photographic macro lens and the high resolution of a microscope objective. 

 

 

 

 

Polarisation and interference methods

20th March 2018.  
W Brad Amos, MRC Laboratory of Molecular Biology, Cambridge              

Abstract 
The third seminar of the Light microscopy series will be given by William B Amos of the MRC Laboratory of Molecular Biology in Cambridge in the College lecture on Tuesday tthe 20th of March at 2.00 pm and will address Polarisation and Interference Methods. The seminar will discuss the nature of polarised light, the way in which polarised light interacts with crystals and biomolecules, differential interference contrast using polarisation and the use of fluorescence in microscopy including fluorescence correlation spectroscopy, fluorescent lifetime measurements and Forster resonance energy transfer.

Biography
William Brad Amos was trained as a zoologist, researched in cell biology and is now a designer of optical instruments. With John White, Mick Fordham and Richard Durbin in Cambridge, he developed an instrument that has set the standard of modern confocal microscopes.  Derivatives of this instrument are now made by many companies and are in use throughout the world. His scientific work is now carried out done in collaboration with Gail McConnell in the University of Strathclyde. This collaboration has resulted in several novel applications of optical physics in microscopy, including what is arguably the greatest design change in microscope objectives  for 100 years. This is called the Mesolens, the name signifying that it has the wide field of a photographic macro lens and the high resolution of a microscope objective. 

 

 

 

 

Ray and wave optics and practical microscopy

19th March 2018.  
W Brad Amos, MRC Laboratory of Molecular Biology, Cambridge              

Abstract 
The second seminar of the Light microscopy series will be given by William B Amos of the MRC Laboratory of Molecular Biology in Cambridge in the College lecture theatre on Monday the 19th of March at 4.00 pm and will address Ray and wave optics and practical microscopy. The seminar will discuss standardised distances in compound microscopes, lens aberrations, diffraction in the light microscope, Rayleigh resolution and Fourier synthesis. The poster of the series can be downloaded here.

Biography
William Brad Amos was trained as a zoologist, researched in cell biology and is now a designer of optical instruments. With John White, Mick Fordham and Richard Durbin in Cambridge, he developed an instrument that has set the standard of modern confocal microscopes.  Derivatives of this instrument are now made by many companies and are in use throughout the world. His scientific work is now carried out done in collaboration with Gail McConnell in the University of Strathclyde. This collaboration has resulted in several novel applications of optical physics in microscopy, including what is arguably the greatest design change in microscope objectives  for 100 years. This is called the Mesolens, the name signifying that it has the wide field of a photographic macro lens and the high resolution of a microscope objective. 

 

 

 

 

Resolution and the nature of optical images

19th March 2018.  
W Brad Amos, MRC Laboratory of Molecular Biology, Cambridge              

Abstract 
The first seminar of the Light microscopy series will be given by William B Amos of the MRC Laboratory of Molecular Biology in Cambridge on Monday the 19th of March in the College lecture theatre at 2.00 pm and will address Resolution and the nature of optical images. The seminar will discuss the nature of images obtained the light microscope, Abbe's equation for resolution as well as recent developments such Interferometric Fluorescent Superresolution Microscopy (iPALM) and Coherent anti-Stokes Raman Spectroscopy (CARS). The poster of the series can be downloaded here.

Biography
William Brad Amos was trained as a zoologist, researched in cell biology and is now a designer of optical instruments. With John White, Mick Fordham and Richard Durbin in Cambridge, he developed an instrument that has set the standard of modern confocal microscopes.  Derivatives of this instrument are now made by many companies and are in use throughout the world. His scientific work is now carried out done in collaboration with Gail McConnell in the University of Strathclyde. This collaboration has resulted in several novel applications of optical physics in microscopy, including what is arguably the greatest design change in microscope objectives  for 100 years. This is called the Mesolens, the name signifying that it has the wide field of a photographic macro lens and the high resolution of a microscope objective. 

 

 

 

 

Sunday, 18 March 2018 22:14

Light Microscopy

The College is organising a major seminar series on Light Microscopy from Monday the 19th of March to Thursday the 22nd.  Light microscopy has undergone dramative developments in the last 10-20 years that culminated in the 2014 Nobel Prize for Chemistry to Eric Betzig, Stefan W Hell and William E Moerner for the development of so-called super resolution fluorescence microscopy. 

The College series will involve a total of 8 seminars (2 per day at 2.00 and 4.00 pm respectively) and will cover both the foundations and the most recent advances in advanced imaging methods, super resolution, localisation microscopy and multi photon microscopy.   All College students are invited to participate, especially students of the Biology, Biotechnology, Bioengineering, Pharmaceutical Sciences and Medicine Courses.  The poster of the series can be downloaded here. Image: DNA inside a cell's nucleus by super-resolution microscopy,

Speakers, dates and topics

William B Amos, Cambridge
Monday 19th March. 2.00 pm
Resolution and the nature of optical images

William B Amos, Cambridge
Monday 19th March. 4.00 pm
Ray and wave optics and practical microscopy

William B Amos, Cambridge
Tuesday 20th March. 2.00 pm
Polarisation and interference methods

William B Amos, Cambridge
Wednesday 21th March. 2.00 pm
New directions in optical microscopy

Rainer Heintzmann, Jena
Tuesday 20th March. 4.00 pm
Super resolution microscopy

Gail McConnell, Strathclyde
Wednesday 21st March. 4.00 pm
Lasers and advanced imaging methods

Susan Cox, London
Thursday 22nd March. 2.00 pm
Localisation microscopy

Veronika AM Te Boekhorst, Houston.
Thursday 22nd March. 4.00 pm
Multiphoton microscopy

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Friday, 08 December 2017 15:28

The Tempo of Cancer

Chi Van Dang, Director of the Ludwig Institute for Cancer Research and a leading cancer researcher based at the Wistar Institute in Philadelphia will give the opening lecture of the PhD Programme of the University of Pavia on Monday the 11th of December in Aula Magna (Strada Nuova) at 10.30.  The lecture, entitled Convergence of Circadian Clock and Cancer: Time as an Inconvenient Truth, will tackle a new area in cancer research that may greatly extend our understanding of the disease.  The poster of the lecture can downloaded here and all College students of Biology, Biotechnology and Medicine are strongly encouraged to attend.  Chi Van Dang will be a guest of the College during his stay in Pavia.

Abstract
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells. In cancer cells, depending on the driving oncogenic event, metabolism is re-wired for nutrient import, redox homeostasis, protein quality control, and biosynthesis to support cell growth and division. In general, resting cells rely on oxidative metabolism, while proliferating cells rewire metabolism toward glycolysis, which favors many biosynthetic pathways for proliferation. Oncogenes such as MYC, BRAF, KRAS, and PI3K have been documented to rewire metabolism in favor of proliferation. These cell intrinsic mechanisms, however, are insufficient to drive tumorigenesis because immune surveillance continuously seeks to destroy neo-antigenic tumor cells. In this regard, evasion of cancer cells from immunity involves checkpoints that blunt cytotoxic T cells, which are also attenuated by the metabolic tumor microenvironment, which is rich in immuno-modulating metabolites such as lactate, 2-hydroxyglutarate, kyneurenine, and the proton (low pH). As such, a full understanding of tumor metabolism requires an appreciation of the convergence of cancer cell intrinsic metabolism and that of the tumor microenvironment including stromal and immune cells.

Biography
Chi Van Dang oversees the execution of Ludwig’s scientific strategy, with a special focus on the operations and staffing of the Lausanne, Oxford and San Diego Branches of the Ludwig Institute for Cancer Research. He also manages the alignment of their efforts with those of the six independent Ludwig Centers across the US to further cultivate collaboration within Ludwig’s global research community. As a researcher, Chi Van Dang is best known for his work on the molecular signaling pathways and mechanisms that govern the unusual metabolism of cancer cells, which require vast quantities of energy and molecular building blocks to sustain proliferation. Chi Van Dang's laboratory was the first to show that a master regulator of gene expression named MYC—a gene whose mutation or aberrant expression is associated with many types of cancer—alters the utilization of a key sugar in cancer cells. This body of work bolstered the hypothesis that cancer cells can become addicted to their reengineered metabolic signaling and that disrupting these pathways could be a powerful approach to treating cancer. Chi Van Dang currently leads a Ludwig laboratory housed at The Wistar Institute in Philadelphia. Prior to joining Ludwig, he served as Director of the Abramson Cancer Center at the University of Pennsylvania Perelman School of Medicine, where he launched a series of Translational Centers of Excellence to develop novel interventions for various cancers. He began his career in medicine and research at Johns Hopkins University School of Medicine, where he was Director of the Division of Hematology and eventually became the Johns Hopkins Family Professor in Oncology Research, the Vice Dean for Research and Director of the Hopkins Institute for Cell Engineering. He has authored over 250 scientific and medical articles, book chapters and two books and am a member of the National Academy of Medicine (Institute of Medicine), American Academy of Arts & Sciences and chair the National Cancer Institute’s Board of Scientific Advisors.

Image courtesy: http://www.eyeofscience.de/en/

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Monday, 04 December 2017 09:34

New students' restaurant

A first class students' restaurant will open tomorrow Tuesday the 5th of December 2017 in via A Bassi, opposite the Department of Physics.  The new restaurant, the result of a project led by EDiSU and carried out in close coordination with the University, will provide a crucial service to undergraduates and postgraduates who study at the Departments located in via T Taramelli, C Forlanini and A Bassi (Chemistry, Pharmaceutical Sciences, Physics, Biochemistry, Physiology, Anatomy, Genetics, Pathology and Forensic Medicine) and to the students of nearby Collegio C Golgi and A Volta.

The new restaurant represents an extensive refurbishment of an earlier facility and provides both the excellent food that students may expect in this part of the world as well as modern and high-quality furniture and logistics.  

College students are warmly invited to attend the opening ceremony tomorrow (12.00 noon) led by EDiSU President P Benazzo, EDiSU Finance Director C Grignani and the Chancellor of the University F Rugge, and make regular use of the new facility.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Monday, 27 November 2017 21:51

Nanosensors & Medicine

G Longo, a scientist at the CNR Institute for the Institute for the Structure of Matter in Rome will give a seminar at 2.00 pm at the Unit of Immunology and General Pathology of the Department of Medicine (9, via A Ferrata).  The seminar is entitled Nanomechanical sensors to study at the nanoscale biomedical challenges and will describe major advances in the field of nanosensor and their applications to biologica and medical problems.

The poster can be found here, the abstract of the seminar can be found here.

All College students, and in particular students in Medicine, Biotechnology, Biology, Chemistry, Physics and Engineering are welcome to attend. 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Monday, 27 November 2017 21:36

EDiSU Welcome Day

EDiSU will hold its traditional, annual welcome day tomorrow in the College lecture theatre at 6.30 pm. 

The event will involve speeches by F Rugge, University Chancellor,  P Benazzo, EDiSU President, and S Pezzini, a post-doctoral fellow at Radboud University in Holland and previously a student in one of the EDiSU College. The poster of the event can be found here.

The speeches will be followed by a reception. All students are welcome to attend.  Attendance by freshers is compulsory.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Page 1 of 29
You are here: Home Articles