Contenuti

Examinations 2014-15

The examination results of College undergraduate and MSc students has continued to improve in the academic year 2014/15 over the the previous two years (2012/13 and 2013/14). A summary of the data is shown in the Fig Examination Results 2014/15. The College had introduced small group, informal teaching (supervisions) on a pilot basis in the academic year 2013/14 and in 2014/15 teaching has extended to four Courses (Calculus, Physics, General Chemistry and Biochimestry for the Science).

As the admission procedure has not changed (students are admitted by EDiSU not on academic merit but on financial grounds), the improved performance of College students clearlys reflect both a commitment by students to perform well and the growing impact of College teaching in several key subjects that often cause problems and delays. The College is determined, therefore in further expanding internal teaching and championing the value of College-base teaching in other EDiSU Colleges.

Ageing and Disease

A one-day colloquium promoted by Collegio A Volta, the University of Pavia and King's College London will take place on the 10th of May in Aula U Foscolo (65, Strada Nuova) and will address recent advances in research on Ageing and Disease

The changes in housing, the increase in food production, progress in the treatment of infectious diseases and general public health measures have not only led to a major increase in the human population but have also more than double human lifespan in the last two hundred years. The link between ageing and disease is a complex and this Colloquium will focus on selected major areas of research.  College students are warmly invited to attend this important lecture. 

Topics of the colloqium include the biological basis of age-associated memory changes, the mechanisms leading to Parkinson's disease, age-associated amyloidosis, age-related changes in skeletal muscles and the cardiovascular system and the potential impact of nutrigenomics in counteracting age-related cardiovascular pathologies.  The poster of the colloquium can be downloaded here. All College students are warmly invited to attend, especially students as the issue of ageing populations and the link between ageing and disease touches on the life of most of us and constitutes a major challenge for society in both medical and financial terms.

Image: scanning electron micrograph a Purkinje neuron. Courtesy of D McCarthy.

Regeneration of the Epidermis

9th April 2018.
Michele De Luca, University of Modena
.

The 2017/18 M Fraccaro Lecture, organised an nually by Collegio Cairoli and Collegio Volta will be given at 5.00 pm on 9th April 2018 in the main University lecture hall (Aula Magna) by Prof M De Luca at the University of Modena. 

Lecture
The lecture entitled: Life-saving regeneration of the entire human epidermis by transgenic stem cells and will illustrate ground-breaking progress in curing a child with a life-threatening skis disease (Junctional epidermolysis bullosa, genetic disease caused by mutations in genes encodingthe basement membrane component laminin 5). The approach pursued by Prof M De Luca and his collaborators involved correction of the faulty gene in skin stem cells in culture followed by propagation and implantation of the cells with the corrected gene to enable the growth of the entire body skin. The results of this study were published in November 2017 in the journal Nature and the article is available here for downloading. All College students are warmly invited to attend this important lecture.  The poster of the lecture can be downloaded here.  The lecture will be followed by refreshments at Collegio Cairoli.

Biography
Michele De Luca has dedicated most of his scientific activities to translational medicine. He is recognised as leading scientist in human squamous epithelial stem cell biology aimed at the development of epithelial stem cell-mediated cell therapy and gene therapy. Following on early work on the use of human epidermal stem cell cultures in life-saving treatment of massive full-thickness burns and in repigmentation of stable vitiligo and piebaldism by keratinocyte/melanocyte co-colture (reviewed in Regen. Med. 2006), Michele De Luca and his historic collaborator Graziella Pellegrini, were first to establish human urethral stem cell culture aimed at urethral regeneration in posterior hypospadias (N. Engl. J. Med. 1990). They then developed human limbal stem cell culture (J. Cell Biol. 1999) for corneal regeneration in patients with severe limbal stem cell deficiency (Lancet 1997; N. Engl. J. Med 2010; Regen. Med. 2013). This treatment leads to recovery of normal vision and is now used worldwide. In February 2015 such cultures were formally approved as an Advanced Therapy Medicinal Product by EMA, which registered them under the name of Holoclar. Holoclar is the first stem cell-based therapy approved in Europe and EMA has indicated it amongst the most relevant achiements in the field in the last 20 years. They have characterised molecular mechanisms regulating long term proliferative potential, clonal evolution and self-renewal of epithelial stem cells. In particular, they shed light on the role of p63 (different isoforms) and c/EBPδ in regulating the proliferative potential and the self-renewal of human corneal stem cells, respectively (PNAS 2001, 2005; J. Cell Biol. 2007). Notably, their work demonstrated that the clinical success of limbal stem cultures is dependent on a discrete number of stem cells identified as holoclones expressing the ΔNα isoform of p63 (N. Engl. J. Med.  2010, TMM 2011, Regen. Med. 2013). Michele De Luca and Pellegrini are also pioneering ex-vivo epithelial stem cell-mediated gene therapy for genetic skin diseases. He coordinated the first successful clinical trial to treat junctional epidermolysis bullosa (JEB) (Nat. Med. 2006; Stem Cell Rep. 2014; J. Invest. Dermatol, 2017; Nature, 2017). JEB is a severe, often lethal genetic disease caused by mutations in genes encoding the basement membrane component laminin-332. Surviving JEB patients develop chronic skin and mucosa wounds, which impair their quality of life and lead to skin cancer. De Luca has recently reported life-saving regeneration of the entire, fully functional, epidermis on a 7-year-old child suffering from a devastating, life-threatening form of JEB (Nature, 2017). Using integrations as clonal genetic marks, he has shown that the vast majority of epidermal TA progenitors are progressively lost within a few months after grafting and the regenerated epidermis is indeed sustained only by a limited number of long-lasting, self-renewing stem cells. This notion argues against a model positing the existence of a population of equipotent epidermal progenitors that directly generate differentiated cells during the lifetime of the animal and fosters a model where specific stem cells persist during the lifetime of the human and contribute to both renewal and repair by giving rise to pools of progenitors that persist for various periods of time, replenish differentiated cells and make short-term contribution to wound healing (Nature, 2017). Based on this notion and on the corneal data (N. Engl. J. Med 2010) De Luca and Pellegrini established that the essential feature of any cultured epithelial grafts is the presence (and preservation) of an adequate number of holoclone-forming cells. Their work thus provides a blueprint that can be applied to other stem cell-mediated ex vivo cell and gene therapies (see N&V Nature 2010). Michele De Luca is internationally recognised for his experience in stem cell therapy and contributed to two reports by the International Society for Stem Cell Research, dealing with new guidelines for responsible translational stem cells research (Cell Stem Cell 2008, 2009).

Image: human keratinocytes in culture. Courtesy of CellnTec.

Matteo Turchetti

I am a second year student in the MSc Course in Biotechnology. I have a strong background in text editing, information retrieval and bibliography software. I have offered the College dissertation course in 2018/18.


2017/18

Dissertation Writing  (All Courses)

01. Prima di iniziare
02. La stesura passo per passo
03. Discussione e bibliografia
04. Attendance


 

 

Antonio Contino

I am a final year student in the Communication, Information and Media Technology Course. I have a strong interest and considerable experience in web design and offered the College Course in 2017/18.


2017/18

Web Design (All University Courses)

01. Introduzione HTML
02. Esercitazione HTML/CSS
03. Introduzione CSS
04. Form, tabelle, tag avazanti (HTML5) & CSS
05. Javascript
06. CMS e WordPress
07. Attendance


 

Ingrid Ouandji

I am a third year undergraduate student entolled in the Pharmacy Course. I am a member of College since October 2017 and a native French speaker with a strong interest in language studies. I offered the  College French Course from November 2017 to March May 2018.


2017/18

French Language 2017/18 (All Courses)

01. Lectures 01-05
02. Lectures 06-10
03. Lectures 11-15
04. Lectures 16-20
05. Attendance

Claudio Neidhöfer

I am a final year medical student enrolled in the Harvey Course at the University of Pavia currently writing my dissertation in the Unit of Immunology and General Pathology of the Department  of Molecular Medicine.  My main fields of interest are the prevention, treatment and possible reversal of the atherosclerotic process.  Beside being a native German speaker I have been teaching German for several years and offered the 2017/18 Course in College.


2017/18

German Language (All University Courses)

01. Lectures 01-10
02. Lectures 11-20
03. Lectures 21-30
04. Lectures 31-40
05. Attendance

 

Giuliano Patanè

I an Italian medical student with a strong personal interest in biochemistry, a fascinating subject, fundamental for a deeper understanding of the molecular basis of disease. I have offered supervisions in Biochemistry to College undergraduates enrolled in the medical course taught in Italian (Golgi Course).


2017/18

 Biochimica (Corso di Laurea: Medicina e Chirurgia in lingua Italiana)

01. Proteine, struttura, esempi e funzionamento
02. Fosforilazione ossidativa
03. Metabolismo glucidico
04. Catabolismo lipidico
05. Ciclo di Krebs
06. Biosintesi dei lipidi
07. Metabolismo degli amino acidi
08. Membrane biologiche
09. Trasduzione del segnale
10. Replicazione del DNA
11. Sintesi proteica
12. Riepilogo per esame
13. Attendance

 


 

Niccolò Di Dio

I am a second year student in the MSc Course in Civil (Construction) Engineering. I have a strong interest in Mathematics and Physics and I have offered supervisions in the General Physics Course for undergraduates of the Chemistry and Biology Courses.


 2017/18

 Fisica Generale (Corsi di Laurea: Chimica, Chimica e Tecnologie Farmaceutiche, Scienze Biologiche, Biotecnologie)

01. Moto in una dimensione
02. Vettori
03. Moto in due dimensioni
04. Dinamica e forze
05. Energia di un sistema
06. Quantita' di moto e urti
07. Rotazione di un corpo rigido attorno ad un asse fisso
08. Carica elettrica, legge di Coulomb, campo elettrostatico (O Najlani)
09. Capacita', condensatori, mezzi dielettrici, corrente elettrica (O Najlani)(O Najlani)
10. Campo elettromagnetico, forza di Lorenz, legge di Ampere(O Najlani)(O Najlani)
11. Momento angolare e oscillazion1
12. Meccanica dei fluidi
13. Attendance


Omar Najlani


I am a final year undergraduate student in Industrial Engineering at the University of Pavia. My main interests focus on the computer science and Mathematics and I have been contributing to the College teaching of both these subjects. I have also offered supervisions on selected topics of a General Physics Course.


 2017/18

 Matematica  (Corsi di Laurea: Chimica, Chima e Tecnologie Farmaceutiche, Scienze Biologiche, Biotecnologie)

01. Insiemi, intervalli, equazioni algebriche, disequazioni algebriche, trigonometria, geometria analitica nel piano
02. Grafico di una funzione reale, grafici e proprietà di alcune funzioni elementari, uomini delle funzioni più' comuni, funzioni composte
03. Funzioni elementari, teoremi sui limiti: teorema diunicita' del limite, teorema di permanenza del segno, teorema del confronto, operazioni sui limiti
04. Limiti notevoli, definizione di continuità', discontinuità' di prima, seconda e terza specie, teoremi sulle funzioni continue
05. Numeri complessi, forma algebrica dei numeri complessi, complesso coniugato, modulo e fase, rappresentazione in forma trigonometrica, formula di Eulero, rappresentazione in forma  esponenziale, formule di De Moivre, serie n, utilizzo, scale semi logaritcmicheumeriche, carattere della serie, alcune proprietà' serie notevoli, scale logaritmiche
06. Polinomi di Taylor, derivate, retta tangente, derivate fondamentali, regole di derivazione, monotonia e segno della derivata, massimi e minimi
07. Concavita' e derivata seconda, funzione convessa, funzione concava, punti di flesso, criterio della derivata seconda, teorema di Fermat, teorema di Lagrange, studio di funzione
08. Introduzione al calcolo integrale, integrale definito, proprietà' dell'integrale definito, funzioni primitive, integrale indefinito, integrali indefiniti immediati
09. Teorema di Torricelli-Barrow, teorema fondamentale del calcolo integrale, integrali impropri, integrazione per sostituzione, integrazione per parti
10. Problema di Cauchy, equazioni differenziali lineari del primo ordine, equazioni differenziali a variabili separabili, equazioni differenziali lineari del secondo ordine
11. Grafico per funzioni di due variabili, linee di livello, derivate parziali, gradiente, derivate direzionali, piano tangente al grafico di una funzione di due variabili, teorema di Schwartz
12. Riepilogo
13. Attendance


2017/18

Fondamenti di Informatica  (Ing Elettronica e informatica, Ing Industriale, Bioingegneria)

01. La shell, hello world, shortcut
02. Variabili e tipi, esercizio
03. Flowchart, strutture di controllo
04. Esempi svolti
05. Esempi svolti cdd, calcolo media
06. Vettori, funzioni
07. Ordinamento, massimo e minimo, trova stringa
08. File I/O in C
09. Lettura con gets e scanf()
10. Attendance


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