The Spread of Antibacterial Resistance

22 May 2018

On the 23rd of May Esther Kuenzli, of the Swiss Tropical and Public Health Institute and the University of Basel, will give a seminar on International spreading of antibacterial resistance at 3.00 pm in the College lecture theatre.

International travel has become on important mechanism for the spreading of antibacterial resistance and notably the spreading of Enterobacteriaceae able to produce extend spectrum be lactamases, enzymes able to inactivate one of the major classes of antibiotics currently available.  E Keuenzli will discuss the impact of international travel on the spread of antibacterial resistance and measures to counteract this major medical problem.

All College students are warmly invited to attend this seminar lecture, espcially students reading Medicine, Biology, Biotechnology and Pharmaceutical Sciences.  The poster of the lecture can be downloaded here.

Multiresistant Tuberculosis

21 May 2018

On the 22nd of May Daniela Cirililo, of the Scientific Institute S Raffaele in Milan, will give a seminar on Multirestiant Tuberculosis at 3.00 pm in the College lecture theatre.

Tuberculosis, a complex infectious disease caused by the bacterium M tuberculosis, is one of the diseases that have shaped the course of human history and that remains inadequately controlled.  Although a vaccine has been available for nearly a century, its efficacy is limited limited and a number of M tuberculosis strains resistant to the antibiotics currently available have emerged over time. D Cirillo will discuss mechainsms of resistance and the impact of the emergence of multiresistant strains for the control of tuberculosis.

All College students are warmly invited to attend this seminar lecture, espcially students reading Medicine, Biology, Biotechnology and Pharmaceutical Sciences.  The poster of the lecture can be downloaded here.

2017/18 M Fraccaro Lecture

08 April 2018

The 2017/18 M Fraccaro Lecture, organised an nually by Collegio Cairoli and Collegio Volta will be given at 5.00 pm on 9th April 2018 in the main University lecture hall (Aula Magna) by Prof M De Luca at the University of Modena. 

The lecture entitled: Life-saving regeneration of the entire human epidermis by transgenic stem cells and will illustrate ground-breaking progress in curing a child with a life-threatening skis disease (Junctional epidermolysis bullosa, genetic disease caused by mutations in genes encodingthe basement membrane component laminin 5). The approach pursued by Prof M De Luca and his collaborators involved correction of the faulty gene in skin stem cells in culture followed by propagation and implantation of the cells with the corrected gene to enable the growth of the entire body skin. The results of this study were published in November 2017 in the journal Nature and the article is available here for downloading.

All College students are warmly invited to attend this important lecture.  The poster of the lecture can be downloaded here.  The lecture will be followed by refreshments at Collegio Cairoli.

Image: a human skin cell, known as keratinocyte, in culture.

Light Microscopy

18 March 2018

The College is organising a major seminar series on Light Microscopy from Monday the 19th of March to Thursday the 22nd.  Light microscopy has undergone dramative developments in the last 10-20 years that culminated in the 2014 Nobel Prize for Chemistry to Eric Betzig, Stefan W Hell and William E Moerner for the development of so-called super resolution fluorescence microscopy. 

The College series will involve a total of 8 seminars (2 per day at 2.00 and 4.00 pm respectively) and will cover both the foundations and the most recent advances in advanced imaging methods, super resolution, localisation microscopy and multi photon microscopy.   All College students are invited to participate, especially students of the Biology, Biotechnology, Bioengineering, Pharmaceutical Sciences and Medicine Courses.  The poster of the series can be downloaded here. Image: DNA inside a cell's nucleus by super-resolution microscopy,

Speakers, dates and topics

William B Amos, Cambridge
Monday 19th March. 2.00 pm
Resolution and the nature of optical images

William B Amos, Cambridge
Monday 19th March. 4.00 pm
Ray and wave optics and practical microscopy

William B Amos, Cambridge
Tuesday 20th March. 2.00 pm
Polarisation and interference methods

William B Amos, Cambridge
Wednesday 21th March. 2.00 pm
New directions in optical microscopy

Rainer Heintzmann, Jena
Tuesday 20th March. 4.00 pm
Super resolution microscopy

Gail McConnell, Strathclyde
Wednesday 21st March. 4.00 pm
Lasers and advanced imaging methods

Susan Cox, London
Thursday 22nd March. 2.00 pm
Localisation microscopy

Veronika AM Te Boekhorst, Houston.
Thursday 22nd March. 4.00 pm
Multiphoton microscopy
























The Tempo of Cancer

08 December 2017

Chi Van Dang, Director of the Ludwig Institute for Cancer Research and a leading cancer researcher based at the Wistar Institute in Philadelphia will give the opening lecture of the PhD Programme of the University of Pavia on Monday the 11th of December in Aula Magna (Strada Nuova) at 10.30.  The lecture, entitled Convergence of Circadian Clock and Cancer: Time as an Inconvenient Truth, will tackle a new area in cancer research that may greatly extend our understanding of the disease.  The poster of the lecture can downloaded here and all College students of Biology, Biotechnology and Medicine are strongly encouraged to attend.  Chi Van Dang will be a guest of the College during his stay in Pavia.

Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells. In cancer cells, depending on the driving oncogenic event, metabolism is re-wired for nutrient import, redox homeostasis, protein quality control, and biosynthesis to support cell growth and division. In general, resting cells rely on oxidative metabolism, while proliferating cells rewire metabolism toward glycolysis, which favors many biosynthetic pathways for proliferation. Oncogenes such as MYC, BRAF, KRAS, and PI3K have been documented to rewire metabolism in favor of proliferation. These cell intrinsic mechanisms, however, are insufficient to drive tumorigenesis because immune surveillance continuously seeks to destroy neo-antigenic tumor cells. In this regard, evasion of cancer cells from immunity involves checkpoints that blunt cytotoxic T cells, which are also attenuated by the metabolic tumor microenvironment, which is rich in immuno-modulating metabolites such as lactate, 2-hydroxyglutarate, kyneurenine, and the proton (low pH). As such, a full understanding of tumor metabolism requires an appreciation of the convergence of cancer cell intrinsic metabolism and that of the tumor microenvironment including stromal and immune cells.

Chi Van Dang oversees the execution of Ludwig’s scientific strategy, with a special focus on the operations and staffing of the Lausanne, Oxford and San Diego Branches of the Ludwig Institute for Cancer Research. He also manages the alignment of their efforts with those of the six independent Ludwig Centers across the US to further cultivate collaboration within Ludwig’s global research community. As a researcher, Chi Van Dang is best known for his work on the molecular signaling pathways and mechanisms that govern the unusual metabolism of cancer cells, which require vast quantities of energy and molecular building blocks to sustain proliferation. Chi Van Dang's laboratory was the first to show that a master regulator of gene expression named MYC—a gene whose mutation or aberrant expression is associated with many types of cancer—alters the utilization of a key sugar in cancer cells. This body of work bolstered the hypothesis that cancer cells can become addicted to their reengineered metabolic signaling and that disrupting these pathways could be a powerful approach to treating cancer. Chi Van Dang currently leads a Ludwig laboratory housed at The Wistar Institute in Philadelphia. Prior to joining Ludwig, he served as Director of the Abramson Cancer Center at the University of Pennsylvania Perelman School of Medicine, where he launched a series of Translational Centers of Excellence to develop novel interventions for various cancers. He began his career in medicine and research at Johns Hopkins University School of Medicine, where he was Director of the Division of Hematology and eventually became the Johns Hopkins Family Professor in Oncology Research, the Vice Dean for Research and Director of the Hopkins Institute for Cell Engineering. He has authored over 250 scientific and medical articles, book chapters and two books and am a member of the National Academy of Medicine (Institute of Medicine), American Academy of Arts & Sciences and chair the National Cancer Institute’s Board of Scientific Advisors.

Image courtesy:






















New students' restaurant

04 December 2017

A first class students' restaurant will open tomorrow Tuesday the 5th of December 2017 in via A Bassi, opposite the Department of Physics.  The new restaurant, the result of a project led by EDiSU and carried out in close coordination with the University, will provide a crucial service to undergraduates and postgraduates who study at the Departments located in via T Taramelli, C Forlanini and A Bassi (Chemistry, Pharmaceutical Sciences, Physics, Biochemistry, Physiology, Anatomy, Genetics, Pathology and Forensic Medicine) and to the students of nearby Collegio C Golgi and A Volta.

The new restaurant represents an extensive refurbishment of an earlier facility and provides both the excellent food that students may expect in this part of the world as well as modern and high-quality furniture and logistics.  

College students are warmly invited to attend the opening ceremony tomorrow (12.00 noon) led by EDiSU President P Benazzo, EDiSU Finance Director C Grignani and the Chancellor of the University F Rugge, and make regular use of the new facility.






















Nanosensors & Medicine

27 November 2017

G Longo, a scientist at the CNR Institute for the Institute for the Structure of Matter in Rome will give a seminar at 2.00 pm at the Unit of Immunology and General Pathology of the Department of Medicine (9, via A Ferrata).  The seminar is entitled Nanomechanical sensors to study at the nanoscale biomedical challenges and will describe major advances in the field of nanosensor and their applications to biologica and medical problems.

The poster can be found here, the abstract of the seminar can be found here.

All College students, and in particular students in Medicine, Biotechnology, Biology, Chemistry, Physics and Engineering are welcome to attend. 





















EDiSU Welcome Day

27 November 2017

EDiSU will hold its traditional, annual welcome day tomorrow in the College lecture theatre at 6.30 pm. 

The event will involve speeches by F Rugge, University Chancellor,  P Benazzo, EDiSU President, and S Pezzini, a post-doctoral fellow at Radboud University in Holland and previously a student in one of the EDiSU College. The poster of the event can be found here.

The speeches will be followed by a reception. All students are welcome to attend.  Attendance by freshers is compulsory.





















VSU Committee

17 November 2017

College students have elected the new Executive Committee of the Volta Students' Union (VSU).  Only six candidates stood for election and a total of 60 students voted (down from > 90 in October 2016). 

The students elected to the Committee are: Paride Maddalena, Monica Passanante, Lucia Fruga, Valentina Astesana, Thanh Hang Bui and Daniele Susca. Paride Maddalena secured the highest number of votes and will act as President of the VSU Committee for 2017/18.

The College wishes to thank the students who made themselves available for serving in the Committee.





















Language Courses

16 November 2017

The much awaited College language Courses will take off next week and will involve nearly hundred students: half studying English, half studying French or German. 

Two English Courses (B2 and C1) will be delivered by an external teacher appointed by EDiSU and were expected to start on Wednesday the 22nd of November.  We have now received a different communication from EDiSU stating that Courses will start next week and will involve lessons on two different days of the week.  This schedule is incompatible with the programme of supervisions and the College will contact EDiSU once more, solve the issue and confirm final arrangements to students. The English classes will take place in Seminar Room 2 (level 2, North wing) at 5.00 pm (B2 class) and 7.00 pm (C1 class).

The French Course, delivered by College member Ingrid R Ouandji, will start on Wednesday the 22nd of November at 5.00 pm in Seminar Room 3 (level 3, North wing).

The German Course, delivered by College member Claudio Neidhoefer, will start on Wednesday the 22nd of November at 8.00 pm in Seminar Room 3 (level 3, North wing).

Students enrolled in the English Courses have been informed of their class assignment. Students who have enrolled in the French and German Courses will be contacted shortly by Ingrid R Ouandji and Claudio Neidhoefer respectively in order to arrange their entrance test.






















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