HMGB1 Protein

On the 10th of December 2018 Marco Bianchi, of Università San Raffaele, will give a seminar entitled High Mobility Group Box 1 protein orchestrates tissue regeneration via CXCR4 at 5.00 pm in the College lecture theatre.  In his talk ME Bianchi will discuss the signaling role of HMGB1 (High Mobility Group Box 1) protein as Damage Associated Molecular Pattern (DMAP) protein. DAMPs are molecules that are normally present inside cells, and whose extracellular presence signals that some cell has died or risks doing so. HMGB1, as the prototypical DAMP, signals tissue damage and triggers inflammation.

This is a major area of research in cancer biology, crucial for understanding the somatic evolution of cancer. All College students are invited to attend, especially those reading Medicine, Biology, Biotechnology and Pharmaceutical Sciences. The poster of the lecture can be downloaded here.  Further information about the seminar, including an abstract, short biography and key references can be found at this page.

Image: human hepatocytes in culture. Liver parenchymal cells are a key target cell population for liver regeneration.





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